Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

Vascular biology of hydrogen sulfide.

Hydrogen sulfide (H2S) is a ubiquitous signaling molecule with important functions in many mammalian organs and systems. Observations in the 1990s ascribed physiological actions to H2S in the nervous system, proposing that this gasotransmitter acts as a neuromodulator. Soon after that, the vasodilating properties of H2S were demonstrated. In the past decade, H2S was shown to exert a multitude o...

Biology for Physiological Hydrogen Sulfide

Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential.

H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversia...

Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.

BACKGROUND The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as a tool to investigate the cardiovascular biology of this gas. METHODS AND R...

Hydrogen Sulfide: Next Potent Preventive and Therapeutic

21 Hydrogen sulfide (H2S) is the third endogenous signaling gasotransmitter, following 22 nitric oxide and carbon monoxide. It is physiologically generated by cystathionine-γ-lyase, 23 cystathionine-β-synthase, and 3-mercaptopyruvate sulfurtransferase. H2S has been gaining 24 increasing attention as an important endogenous signaling molecule because of its 25 significant effects on the cardiova...